What’s Plavix (Clopidogrel Bisulfate)?


MNT Knowledge Center

Plavix (clopidogrel disulfate) is really a medication that stops platelets from clumping together and developing thrombus. This prescription medication helps bloodstream flow easier, and reduces the likelihood of the next stroke or cardiac arrest.

Plavix is definitely an dental, thienopyridine class antiplatelet agent. Antiplatelet agents reduce the accumulation of platelets, thus inhibiting thrombus (clot) formation. Antiplatelet agents work well within the circulation from the arterial blood vessels, where anticoagulants aren’t.

Cholesterol-lowering, antihypertensive, and antiplatelet drugs

Many people are on cholesterol and bloodstream pressure medications (antihypertensive drugs) in lowering their chance of creating a stroke or heart attack.

Antihypertensive medications operate in a number of different ways. Although some reduce the level of bloodstream, others dilate the bloodstream vessels, or alleviate the strain on the circulation system.

Cholesterol-lowering medications usually reduce plaque accumulation, as well as lowering producing cholesterol.

Cholesterol lowering and antihypertensive drugs do help lower overall cardiovascular risk, but they don’t steer clear of the platelets from clumping together to create clots. Plaxix does that – it will help prevent the next stroke or cardiac arrest by continuing to keep the platelets apart by stopping them from sticking with one another and developing clots.

Plavix can be used to avoid thrombus in patients..:

..who lately had cardiac arrest

..who lately were built with a stroke

..with coronary heart (CAD) – when a number of arterial blood vessels don’t supply enough bloodstream towards the heart, usually caused since the arterial blood vessels have hardened (coronary artery disease).

CAD causes many illnesses and deaths. It starts when plaques (hard cholesterol substances) collect inside a heart. Because the plaques develop, they can result in the development of small thrombus which could block bloodstream flow towards the heart muscle.

The individual encounters angina pectoris (chest discomfort), he/she are affected a myocardial infarction (cardiac arrest), or sudden dying. CAD people are generally given balloon angioplasty, bypass surgery, and stents.

..with peripheral vascular disease (PVD) – illnesses from the bloodstream vessels not attached to the heart. The peripheral bloodstream vessels narrow, and bloodstream flow is fixed. It has a tendency to occur mostly within the legs, and often the arms.

Initially, the individual might have achy and tired quads, particularly when walking. Signs and symptoms might have to go away during rest.

Because the disease will get worse, signs and symptoms can look in light effort eventually they’ll be present constantly. Once the disease is severe, the lower limb and feet may go through cold when touched the individual will feel persistent numbness. Sometimes gangrene can be cultivated.

with cerebrovascular disease – disease of bloodstream vessels supplying bloodstream and oxygen towards the brain, especially arterial blood vessels. People are at a bad risk of stroke.

A 2009 study transported out by researchers from McMaster College in Hamilton, Ontario, Canada, discovered that patients with atrial fibrillation (irregular heart rhythms) who couldn’t take anticoagulants (warfarin), and required aspirin with Plavix, were built with a 28% lower chance of stroke. (Connect to article)

Plavix (clopidogrel disulfate) is created and marketed by pharmaceutical companies Sanofi and Bristol-Myers Squibb

Plavix – Important Safety Information

Some genetics may counteract Plavix, departing the individual weaker to stroke and cardiac arrest. Some doctors recommend an inherited test before choosing treatment. Some patients cannot metabolize the drug proberly to transform it to the active make up the Food and drug administration added a boxed warning this year. (Connect to article)

Some medications may counteract Plavix, departing the individual in a greater chance of stroke or heart attack. These include Nexium and Prilosec (proton pump inhibitors), fluvastatin (Lescol) torsemide (Demadex) phenytoin (Dilantin) tamoxifen (Nolvadex) tolbutamide (Orinase) some bloodstream thinners, along with other drugs.

Make certain your doctors learn about all of the medications you’re taking in advance.

Never cease taking Plavix without checking together with your physician. This type of move may lift up your chance of getting a stroke or cardiac arrest.

Plavix, taken alongside some medications, for example aspirin, could raise the chance of potentially existence-threatening bleeding. Your doctors needs to understand about all of the medications you’re taking.

Inform your physician immediately if you’re on Plavix and experience confusion, weakness, or perhaps a fever. They may be indications of TTP (Thrombotic thrombocytopenic purpura).

Individuals with stomach ulcers should avoid using Plavix.

What exactly are reported negative effects associated with taking Plavix?

TTP (Thrombotic Thrombocytopenic Purpura) – a bloodstream clotting problem. Clots form in bloodstream vessels in almost any area of the body. TTP needs immediate medical assistance, otherwise the individual might be vulnerable to dying. The next signs and signs and symptoms ought to be given serious attention and medical help ought to be searched for immediately: pupura (purple stops) within the skin or mucous membrane from the mouth, jaundice, extreme fatigue and/or weakness, very pale skin, fever, faster heartbeat, panting when stationary, vision changes, nausea, vomiting, diarrhea, abdominal discomfort, small quantities of urine, urine is pink (has bloodstream), stroke, seizure, speech changes, headache, along with a feeling you’re going to faint.